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Paper   IPM / Biological Sciences / 17300
School of Biological Sciences
  Title:   Identification of repurposed drugs targeting significant long non-coding RNAs in the cross-talk between diabetes mellitus and Alzheimers disease
  Author(s): 
1.  Shokoofeh Ghiam
2.  Changiz Eslahchi
3.  Koorosh Shahpasand
4.  Mehran Habibi-Rezaei
5.  Sajjad Gharaghani
  Status:   Published
  Journal: Scientific Reports
  Year:  2022
  Supported by:  IPM
  Abstract:
The relationship between diabetes mellitus (DM) and Alzheimer’s disease (AD) is so strong that scientists called it “brain diabetes”. According to several studies, the critical factor in this relationship is brain insulin resistance. Due to the rapid global spread of both diseases, overcoming this cross-talk has a significant impact on societies. Long non-coding RNAs (lncRNAs), on the other hand, have a substantial impact on complex diseases due to their ability to influence gene expression via a variety of mechanisms. Consequently, the regulation of lncRNA expression in chronic diseases permits the development of innovative therapeutic techniques. However, developing a new drug requires considerable time and money. Recently repurposing existing drugs has gained popularity due to the use of low-risk compounds, which may result in cost and time savings. in this study, we identified drug repurposing candidates capable of controlling the expression of common lncRNAs in the cross-talk between DM and AD. We also utilized drugs that interfered with this cross-talk. To do this, high degree common lncRNAs were extracted from microRNA-lncRNA bipartite network.

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